Research progress of necroptosis on bone related diseases / 中国骨伤
China Journal of Orthopaedics and Traumatology
; (12): 687-690, 2021.
Article
em Zh
| WPRIM
| ID: wpr-888340
Biblioteca responsável:
WPRO
ABSTRACT
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Proteínas Quinases
/
Apoptose
/
Necroptose
Idioma:
Zh
Revista:
China Journal of Orthopaedics and Traumatology
Ano de publicação:
2021
Tipo de documento:
Article