Prognostic Significance of Defining L-Cell Type on the Biologic Behavior of Rectal Neuroendocrine Tumors in Relation with Pathological Parameters / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
; : 813-822, 2015.
Article
em En
| WPRIM
| ID: wpr-90558
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: In 2010, the World Health Organization categorized L-cell type neuroendocrine tumors (NETs) as tumors of uncertain malignancy, while all others were classified as malignant. However, the diagnostic necessity of L-cell immunophenotyping is unclear, as are tumor stage and grade that may guide diagnosis and management. To clarify the predictive markers of rectal neuroendocrine neoplasms (NENs), 5- and 10-year overall survival (OS) was analyzed by pathological parameters including L-cell phenotype. MATERIALS AND METHODS: A total of 2,385 rectal NENs were analyzed from our previous multicenter study and a subset of 170 rectal NENs was immunophenotyped. RESULTS: In univariate survival analysis, tumor grade (p 10, is useful in defining L-Cell type. In this study, an L-cell immunophenotype was found in 83.5% of all rectal NENs and most, but not all L-cell type tumors were NET G1, small (< 10 mm) and confined to the mucosa/submucosa. CONCLUSION: From these results, the biological behavior of rectal NENs does not appear to be determined by L-cell type alone but instead by a combination of pathological parameters.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Fenótipo
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Prognóstico
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Neoplasias Retais
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Organização Mundial da Saúde
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Glucagon
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Imuno-Histoquímica
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Classificação Internacional de Doenças
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Análise Multivariada
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Imunofenotipagem
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Tumores Neuroendócrinos
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Prognostic_studies
Idioma:
En
Revista:
Cancer Research and Treatment
Ano de publicação:
2015
Tipo de documento:
Article