PTK2B affects the levels of Aβ in blood and brain and behavioral functions via targeting LRP-1 transporter in Aβ-induced cognitive dysfunction mice / 生理学报
Acta Physiologica Sinica
; (6): 845-854, 2021.
Article
em Zh
| WPRIM
| ID: wpr-921288
Biblioteca responsável:
WPRO
ABSTRACT
The aim of the present study was to explore the correlation between ptk2b/PTK2B (protein tyrosine kinase 2 beta, a ptk2b-encoded protein) and the level of low density lipoprotein receptor-related protein-1 (LRP-1), as well as to uncover the relationship between the changes in beta amyloid protein (Aβ) levels in blood and brain and the expression of ptk2b in Aβ-induced cognitive dysfunction mice. A total of 64 3-month-old C57BL/6J mice were divided randomly into the experimental group and control group. All mice underwent the intracerebroventricular (i.c.v.) intubation. Mice in the experimental group received the i.c.v. infusion of oligomeric Aβ
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fragmentos de Peptídeos
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Encéfalo
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Peptídeos beta-Amiloides
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Modelos Animais de Doenças
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Quinase 2 de Adesão Focal
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Doença de Alzheimer
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Disfunção Cognitiva
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Hipocampo
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Camundongos Endogâmicos C57BL
Limite:
Animals
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2021
Tipo de documento:
Article