Your browser doesn't support javascript.
loading
Value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia / 中国当代儿科杂志
Zhongguo dangdai erke zazhi ; Zhongguo dangdai erke zazhi;(12): 1021-1026, 2021.
Article em En | WPRIM | ID: wpr-922385
Biblioteca responsável: WPRO
ABSTRACT
OBJECTIVES@#To study the value of serum miR-922 and miR-506 expression levels in the diagnosis and prognostic assessment of childhood acute lymphoblastic leukemia (ALL).@*METHODS@#A total of 132 children with ALL (ALL group) and 80 healthy children (healthy control group) were prospectively selected in this study. Quantitative real-time polymerase chain reaction was used to measure the expression levels of serum miR-922 and miR-506 in both groups. Receiver operating characteristic (ROC) curves were plotted to analyze the diagnostic value of miR-922 and miR-506 for childhood ALL. The Kaplan-Meier method was used to plot survival curves, and multivariate COX regression models were used to analyze the risk factors for poor prognosis in children with ALL.@*RESULTS@#The ALL group had significantly higher expression levels of serum miR-922 and miR-506 than the control group (@*CONCLUSIONS@#The expression levels of miR-922 and miR-506 are of good value in the diagnosis and prognostic assessment of childhood ALL.
Assuntos
Palavras-chave
Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Biomarcadores Tumorais / Curva ROC / MicroRNAs / Estimativa de Kaplan-Meier / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Child / Humans Idioma: En Revista: Zhongguo dangdai erke zazhi Ano de publicação: 2021 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Prognóstico / Biomarcadores Tumorais / Curva ROC / MicroRNAs / Estimativa de Kaplan-Meier / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Child / Humans Idioma: En Revista: Zhongguo dangdai erke zazhi Ano de publicação: 2021 Tipo de documento: Article