From MAFLD to hepatocellular carcinoma and everything in between / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 547-556, 2022.
Article
em En
| WPRIM
| ID: wpr-927546
Biblioteca responsável:
WPRO
ABSTRACT
Metabolic (dysfunction) associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most common cause of chronic liver disease worldwide. Many risk factors contribute to the pathogenesis of MAFLD with metabolic dysregulation being the final arbiter of its development and progression. MAFLD poses a substantial economic burden to societies, which based on current trends is expected to increase over time. Numerous studies have addressed various aspects of MAFLD from its risk associations to its economic and social burden and clinical diagnosis and management, as well as the molecular mechanisms linking MAFLD to end-stage liver disease and hepatocellular carcinoma. This review summarizes current understanding of the pathogenesis of MAFLD and related diseases, particularly liver cancer. Potential therapeutic agents for MAFLD and diagnostic biomarkers are discussed.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Fatores de Risco
/
Carcinoma Hepatocelular
/
Hepatopatia Gordurosa não Alcoólica
/
Neoplasias Hepáticas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2022
Tipo de documento:
Article