Role and mechanism of non-coding RNA in the pathogenesis of acute kidney injury / 生理学报
Acta Physiologica Sinica
; (6): 39-46, 2022.
Article
em Zh
| WPRIM
| ID: wpr-927579
Biblioteca responsável:
WPRO
ABSTRACT
Acute kidney injury (AKI) is a common clinical syndrome and an independent risk factor of chronic kidney disease and end-stage renal failure. At present, the treatments of AKI are still very limited and the morbidity and mortality of AKI are rising. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs (circRNAs), are RNAs that are transcribed from the genome, but not translated into proteins. It has been widely reported that ncRNA is involved in AKI caused by ischemia reperfusion injury (IRI), drugs and sepsis through different molecular biological mechanisms, such as apoptosis and oxidative stress response. Therefore, ncRNAs are expected to become a new target for clinical prevention and treatment of AKI and a new biomarker for early warning of the occurrence and prognosis of AKI. Here, the role and mechanism of ncRNA in AKI and the research progress of ncRNA as biomarkers are reviewed.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Traumatismo por Reperfusão
/
RNA não Traduzido
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MicroRNAs
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Injúria Renal Aguda
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RNA Longo não Codificante
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RNA Circular
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2022
Tipo de documento:
Article