Factors Influencing Alzheimer's Disease Risk: Whether and How They are Related to the APOE Genotype / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 809-819, 2022.
Article
em En
| WPRIM
| ID: wpr-939834
Biblioteca responsável:
WPRO
ABSTRACT
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease featuring progressive cognitive impairment. Although the etiology of late-onset AD remains unclear, the close association of AD with apolipoprotein E (APOE), a gene that mainly regulates lipid metabolism, has been firmly established and may shed light on the exploration of AD pathogenesis and therapy. However, various confounding factors interfere with the APOE-related AD risk, raising questions about our comprehension of the clinical findings concerning APOE. In this review, we summarize the most debated factors interacting with the APOE genotype and AD pathogenesis, depict the extent to which these factors relate to APOE-dependent AD risk, and discuss the possible underlying mechanisms.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Apolipoproteínas E
/
Fatores de Risco
/
Doenças Neurodegenerativas
/
Metabolismo dos Lipídeos
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Apolipoproteína E4
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Doença de Alzheimer
/
Genótipo
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Neuroscience Bulletin
Ano de publicação:
2022
Tipo de documento:
Article