Research progress on the mechanism of hepatocarcinogenesis and development in tumor acidic environment / 中华肝胆外科杂志

ABSTRACT

Primary hepatocellular carcinoma (HCC) is one of the high-risk solid tumors in China. Although there has been more comprehensive progress on HCC caricinogenesis, migration and invasion, the 5-year survival is still poor. In recent years, it has been identified that tumor acidic microenvironment may promote the occurrence and development of hepatocellular carcinoma. In this paper, combined with the latest research at home and abroad, the research progress on the occurrence and development of hepatocellular carcinoma under an acidic environment was reviewed.