Research progress on correlation of intestinal flora and its metabolites with small vascular disease in adult population / 中华老年医学杂志

ABSTRACT

Cerebral small vessel disease is common in elderly patients, and its main pathological change is small vessel dysfunction.In addition to common stroke events, the clinical manifestations can also be manifested as cognitive dysfunction.The intestinal flora of elderly patients with small vascular disease often changes, and the relevant altered metabolites can participate in the occurrence and development of small vascular disease through inflammatory response, immune response and changes in blood brain barrier permeability.Understanding the research progress of intestinal flora and its metabolites in small vascular disease can provide theoretical basis for the intervention of intestinal flora in patients with small vascular disease.