Ospemifene: A Novel Option for the Treatment of Vulvovaginal Atrophy
Journal of Menopausal Medicine
; : 79-84, 2017.
Article
em En
| WPRIM
| ID: wpr-97801
Biblioteca responsável:
WPRO
ABSTRACT
Ospemifene—a third-generation selective estrogen receptor modulator approved by the Food and Drug Administration in 2013—is an oral medication for the treatment of dyspareunia. In postmenopausal women with vulvovaginal atrophy, ospemifene significantly improves the structure and pH levels of the vagina, reducing dyspareunia. It is available as a 60-mg tablet; hence, women who may have had prior difficulty with vaginal administration or on-demand use of nonprescription lubricants and moisturizers would likely prefer this form of treatment. Preclinical studies demonstrated that ospemifene has an estrogen agonist action on the bone, reducing the cell proliferation of ductal carcinoma in an in situ model. Studies evaluating the safety of treatment for up to 52 weeks have shown that ospemifene is a safe medication with minimal impact on the endometrium. Further studies with larger number of subjects are necessary to better conclude its effects and long-term safety.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Atrofia
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Tamoxifeno
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United States Food and Drug Administration
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Vagina
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Vulva
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Administração Intravaginal
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Menopausa
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Moduladores Seletivos de Receptor Estrogênico
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Carcinoma Ductal
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Proliferação de Células
Limite:
Female
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Humans
Idioma:
En
Revista:
Journal of Menopausal Medicine
Ano de publicação:
2017
Tipo de documento:
Article