Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection
Immune Network
; : 219-232, 2016.
Article
em En
| WPRIM
| ID: wpr-97832
Biblioteca responsável:
WPRO
ABSTRACT
Production of high affinity antibodies for antigens is a critical component for the immune system to fight off infectious pathogens. However, it could be detrimental to our body when the antigens that B cells recognize are of self-origin. Follicular helper T, or Tfh, cells are required for the generation of germinal center reactions, where high affinity antibody-producing B cells and memory B cells predominantly develop. As such, Tfh cells are considered as targets to prevent B cells from producing high affinity antibodies against self-antigens, when high affinity autoantibodies are responsible for immunopathologies in autoimmune disorders. This review article provides an overview of current understanding of Tfh cells and discusses it in the context of animal models of autoimmune diseases and allograft rejections for generation of novel therapeutic interventions.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Autoanticorpos
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Autoantígenos
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Doenças Autoimunes
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Linfócitos B
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Autoimunidade
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Centro Germinativo
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Modelos Animais
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Aloenxertos
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Sistema Imunitário
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Memória
Idioma:
En
Revista:
Immune Network
Ano de publicação:
2016
Tipo de documento:
Article