Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 757-766, 2023.
Article
em En
| WPRIM
| ID: wpr-980874
Biblioteca responsável:
WPRO
ABSTRACT
Long non-coding RNAs (lncRNAs) reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers. The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers. Notably, JPX participates in cancer growth, metastasis, and chemoresistance, by acting as a competing endogenous RNA for microRNA, interacting with proteins, and regulating some specific signaling pathways. Moreover, JPX may serve as a potential biomarker and therapeutic target for the diagnosis, prognosis, and treatment of cancer. The present article summarizes our current understanding of the structure, expression, and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Regulação da Expressão Gênica
/
MicroRNAs
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Inativação do Cromossomo X
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RNA Longo não Codificante
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2023
Tipo de documento:
Article