New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 551-560, 2023.
Article
em En
| WPRIM
| ID: wpr-982724
Biblioteca responsável:
WPRO
ABSTRACT
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
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Índice:
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Assunto principal:
Plantas Medicinais
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Espectroscopia de Ressonância Magnética
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Estrutura Molecular
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Leonurus
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Componentes Aéreos da Planta
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Diterpenos
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2023
Tipo de documento:
Article