The expression of NGF after rat diffuse axonal injury / 法医学杂志
Journal of Forensic Medicine
; (6): 172-174, 2008.
Article
em Zh
| WPRIM
| ID: wpr-983375
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To study the expression of nerve growth factor (NGF) in diffuse axonal injury (DAI) in rat.@*METHODS@#Eighty SD rats were used and samples were taken at 1 h, 3 h, 6 h, 12 h, 24 h, 48 h, 3 d, and 7 d after brain injury. The expressions of NGF in cerebral cortex, thalamus, cerebellum, and hippocampus were studied with immunohistochemistry and compared with normal group and sham operation group.@*RESULTS@#Low expression of NGF was observed in normal group and sham operation group. The expression of NGF increased 1 h after injury, peaked at 12 h, and returned to basal level at day 7.@*CONCLUSION@#NGF is involved in repair of DAI. The changes of NGF expression following DAI may be applied to estimate the post-injury time interval of the brain in forensic medicine.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Lesões Encefálicas
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Distribuição Aleatória
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Ratos Sprague-Dawley
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Lesão Axonal Difusa
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Patologia Legal
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Fatores de Crescimento Neural
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2008
Tipo de documento:
Article