Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats / 法医学杂志
Journal of Forensic Medicine
; (6): 253-256, 2014.
Article
em Zh
| WPRIM
| ID: wpr-983912
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE@#To test cathepsin L as a biomarker of myocardial ischemia by examination of cathepsin L expression in plasma after myocardial ischemia and ischemia-reperfusion in rats.@*METHODS@#The rat models were established and divided in acute myocardial ischemia model (myocardial ischemia 30 min, 1 h, 2 h groups), ischemia-reperfusion model (ischemia-reperfusion group), and isoflurane-pretreated ischemia-reperfusion model (isoflurane-pretreated group), respectively. Normal control group and sham-operated group were established as contrast. The contents of cathepsin L in plasma were examined by ELISA and myocardial infarction areas were measured after TTC staining.@*RESULTS@#No statistical significant changes were found among the experimental groups compared with the normal control group and sham-operated group (P>0.05). The cathepsin L from the ischemia-reperfusion group increased to 2.37 times compared with the normal control group (P<0.05). The cathepsin L and myocardium infarction size of isoflurane-pretreated group decreased compared with the ischemia-reperfusion group (P<0.05).@*CONCLUSION@#The cathepsin L in plasma is not a promising biomarker of acute myocardial ischemia. Isoflurane preconditioning can reduce the cathepsin L in plasma caused by ischemia-reperfusion injury.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Biomarcadores
/
Traumatismo por Reperfusão Miocárdica
/
Isquemia Miocárdica
/
Catepsina L
/
Isoflurano
/
Infarto do Miocárdio
/
Miocárdio
Limite:
Animals
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2014
Tipo de documento:
Article