Microdeletion and Mutation of Y Chromosome in Full Sibling Identification / 法医学杂志
Journal of Forensic Medicine
; (6): 438-440, 2016.
Article
em Zh
| WPRIM
| ID: wpr-984875
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES@#To explore the identification method of full sibling between two males with microdeletion and mutation of Y chromosome.@*METHODS@#DNA were extracted from two samples. The type testing of Y-STR and autosomal STR were performed. Full sibling between two individuals was calculated by IBS, ITO and discriminant functions methods.@*RESULTS@#There were 2 loci mutations existed in 33 Y-STR loci and one of the two samples had 19 loci deletions. The IBS of two samples was 53 and greater than the threshold which was 42; FSI was 1.36×10¹⁶ and far greater than 19. The discriminant function of full sibling-unrelated individual DFS2 was greater than DR2, which meant the two individuals tend to be full sibling.@*CONCLUSIONS@#The methods of IBS, ITO and discriminant functions of full sibling-unrelated individual can be used comprehensively to provide more reliable expert opinion in microdeletion and mutation of Y chromosome in full sibling identification.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Análise Discriminante
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Reação em Cadeia da Polimerase
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Aberrações Cromossômicas
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Deleção de Sequência
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Cromossomos Humanos Y
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Irmãos
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Alelos
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Genética Forense
Limite:
Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2016
Tipo de documento:
Article