Identification of New Designer Benzodiazepine Diclazepam in Drug Facilitated Sexual Assault / 法医学杂志
Journal of Forensic Medicine
; (6): 248-252, 2018.
Article
em Zh
| WPRIM
| ID: wpr-984931
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVES@#To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault, in order to solve the problem in actual cases.@*METHODS@#The milky fluid from an actual case was extracted and analyzed using LC-QE, ¹H-NMR and GC-MS, respectively. The accurate masses and cluster ions isotope patterns of unknown compound were obtained by LC-QE. The molecular formula was confirmed as C₁₆H₁₂C₂N₂O based on the protons number of ¹H-NMR. The isomers diclazepam and 4-chlorodiazepam were separated and detected with GC-MS.@*RESULTS@#The new designer benzodiazepine as diclazepam in the milky fluid was identified. The results provided direct evidence for the investigation and qualitative analysis of such cases.@*CONCLUSIONS@#The combined application of various methods, including LC-QE, ¹H-NMR and GC-MS, can be used to detect unknown new psychoactive substances.
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Texto completo:
1
Índice:
WPRIM
Assunto principal:
Delitos Sexuais
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Espectrometria de Massas
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Toxicologia
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Benzodiazepinas
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Benzodiazepinonas
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Drogas Desenhadas
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Detecção do Abuso de Substâncias
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Cromatografia Líquida
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Cromatografia Gasosa-Espectrometria de Massas
Limite:
Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Ano de publicação:
2018
Tipo de documento:
Article