Efficacy and predictors of the virologic response to entecavir therapy in nucleoside-naive patients with chronic hepatitis B / 대한간학회지
The Korean Journal of Hepatology
; : 57-65, 2010.
Article
em Ko
| WPRIM
| ID: wpr-98610
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS:
The aim of this study was to elucidate the antiviral efficacy and the predictors of entecavir treatment in nucleoside-naive chronic hepatitis B patients.METHODS:
A total of 160 patients treated with entecavir (0.5 mg daily) for at least 24 weeks were consecutively enrolled. The virologic response (HBV DNA1 log10 copies/mL increase in HBV DNA level above nadir on two consecutive occasions) were retrospectively analyzed.RESULTS:
The mean follow-up duration was 58.8 weeks, and 85 patients (53.1%) showed HBeAg positivity. The median pretreatment levels of serum ALT and HBV DNA were 99 IU/L and 7.6 log10 copies/mL, respectively. The cumulative rates at 12, 24, 48, and 72 weeks were 37.5%, 68.1%, 87.4%, and 95.8%, respectively, for the virologic response; 40.0%, 66.2%, 84.5%, and 92.7% for the biochemical response; 10.6%, 18.8%, 27.0%, and 34.5% for HBeAg loss; and 3.5%, 7.1%, 9.0%, and 13.2% for HBeAg seroconversion. There was no case of virologic breakthrough. An absence of HBeAg and a low serum HBV DNA level (<8 log10 copies/mL) at baseline were significant predictors of the virologic response in a multivariate analysis (P<0.01).CONCLUSIONS:
Entecavir therapy showed excellent efficacy in nucleoside-naive chronic hepatitis B patients. The predictors of a virologic response were an absence of HBeAg and a low baseline HBV DNA level.Palavras-chave
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Assunto principal:
Antivirais
/
Fatores de Tempo
/
DNA Viral
/
Valor Preditivo dos Testes
/
Estudos Retrospectivos
/
Hepatite B Crônica
/
Alanina Transaminase
/
Genótipo
/
Guanina
/
Antígenos E da Hepatite B
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
Ko
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2010
Tipo de documento:
Article