Genetic susceptibility to drug-induced liver injury / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 653-658, 2023.
Article
em Zh
| WPRIM
| ID: wpr-986187
Biblioteca responsável:
WPRO
ABSTRACT
Drug-induced liver injury (DILI) risk prediction, diagnosis establishment, clinical management, and all other aspects are facing great challenges. Although the current understanding of its pathogenesis is still incomplete, research over the past 20 years has shown that genetic susceptibility may play an important role in the occurrence and development of DILI. In recent years, pharmacogenomics studies have further revealed the association between human leukocyte antigen (HLA) genes, some non-HLA genes, and hepatotoxicity from certain drugs. However, due to the lack of well-designed, prospective, large-sample cohort validation and low positive predictive values, there may still be some way to go before the current results can be truly translated into clinical practice for precise prediction and prevention of DILI risk.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Estudos Prospectivos
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Fatores de Risco
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Predisposição Genética para Doença
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
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Doença Hepática Induzida por Substâncias e Drogas
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Fígado
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2023
Tipo de documento:
Article