Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic Virus Type 1: prevalence, clinical aspects and proviral load
Braz. j. infect. dis
; Braz. j. infect. dis;23(2): 95-101, Mar.-Apr. 2019. tab
Article
в En
| LILACS
| ID: biblio-1011574
Ответственная библиотека:
BR1.1
ABSTRACT
ABSTRACT Background:
The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described.Purpose:
To determine the prevalence and associated factors of HTLV-1/KCS in a large cohort of HTLV-1-infected individuals living in Salvador, Brazil.Methods:
A cross-sectional study was conducted between June 2004 and September 2017 at the Integrative and Multidisciplinary Center for HTLV in Salvador, Bahia-Brazil. Data from 758 HTLV-1-infected patients was collected. A complete ophthalmologic examination was performed in both eyes. Lacrimal function was evaluated by breakup time, Rose Bengal and Schirmer I Tests. KCS diagnosis was considered in the presence of at least two out of three positive tests. HTLV-1 proviral load Crude and Adjusted Prevalence Rates (PR) with 95% Confidence Intervals (95% CI) were estimated using multivariate Poisson Regression with robust error variance.Results:
The overall prevalence of KCS was 31.7%, with higher rates observed in HTLV-1-associated myelopathy/tropical spastic paraparesis patients (crude PR 1.84; CI95% 1.50-2.26) even after adjusting for age, sex, time of HTLV-1 diagnosis and schooling (adjusted PR 1.63; CI95% 1.31-2.02). Proviral load, low corrected visual acuity, burning and/or pain and itching were all significantly higher in patients with KCS.Conclusion:
Burning and/or pain and itching and low corrected visual acuity were the most common alterations of HTLV-1/KCS. High Proviral load was found to be associated with the presence of KCS. It is strongly recommended that HTLV-1 patients undergo periodic ophthalmologic examination to promote the early diagnosis of KCS and prevent the consequences associated with dry eye disease.Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Human T-lymphotropic virus 1
/
Keratoconjunctivitis Sicca
Тип исследования:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Пределы темы:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Male
Страна как тема:
America do sul
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Brasil
Язык:
En
Журнал:
Braz. j. infect. dis
Тематика журнала:
DOENCAS TRANSMISSIVEIS
Год:
2019
Тип:
Article