Positive Correlation Between the Level of Interferon-Gamma and the Severity of Periodontitis
Pesqui. bras. odontopediatria clín. integr
; 19: e5106, 2019. tab, graf
Article
в En
| LILACS, BBO
| ID: biblio-1056835
Ответственная библиотека:
BR1264.1
ABSTRACT
Abstract Objective:
To examine the IFN-γ levels in patients with periodontitis and determine the difference in the levels of IFN-γ with the severity of the disease. Material andMethods:
The study design was cross-sectional, and the sample consisted of 31 patients, aged between 18 and 64 years. Plaque index (PlI), calculus index (CI), and papillary bleeding index (PBI) were measured. Pocket depth (PD), recession, and clinical attachment loss (CAL) (mm) were measured at six sites per teeth. For mild/moderate periodontitis, pocket depth ≥4 mm in 1-3 sites was required, while the essential criteria for severe periodontitis were pocket depth ≥5 mm, clinical attachment loss >3 mm in more than 3 sites ≥2 quadrants. The IFN-γ levels were measured by performing enzyme-linked immunosorbent assay with the gingival crevicular fluid (GCF) samples. The measurements were made in two different sites, and the severity of periodontitis was categorized based on the pocket depth, attachment loss, and the remaining natural teeth. Kruskal-Wallis test, Mann-Whitney test, and Spearman's rank correlation coefficient wereResults:
The levels of IFN-γ (pg/mL) were correlated with the severity of the periodontal status, with p <0.05. Clinical parameters of periodontitis also correlated with the level of IFN-γ (pg/mL)Conclusion:
Subjects with periodontitis presented greater levels of IFN-γ (pg/mL) in GCF than the periodontal healthy individuals. This result showed the role of IFN-γ in the inflammation.Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Periodontitis
/
Enzyme-Linked Immunosorbent Assay
/
Gingival Crevicular Fluid
/
Interferon-gamma
Тип исследования:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Пределы темы:
Adult
/
Female
/
Humans
/
Male
Страна как тема:
Asia
Язык:
En
Журнал:
Pesqui. bras. odontopediatria clín. integr
Тематика журнала:
ODONTOLOGIA
Год:
2019
Тип:
Article