In vitro-induction of metronidazole-resistant Giardia duodenalis is not associated with nucleotide alterations in the genes involved in pro-drug activation
Mem. Inst. Oswaldo Cruz
; 115: e200303, 2020. tab, graf
Article
в En
| LILACS, SES-SP
| ID: biblio-1135270
Ответственная библиотека:
BR1.1
ABSTRACT
Giardiasis is an infectious disease caused by Giardia duodenalis. The pro-drug metronidazole (MTZ) is the first-line treatment for giardiasis. Parasite's proteins as pyruvateferredoxin oxidoreductase (PFOR), ferredoxin (Fd), nitroreductase-1 (NR-1) and thioredoxin reductase (TrxR) participate in MTZ activation. Here, we showed Giardia trophozoites long-term exposed to MTZ presented higher IC50 than controls, showing the drug influenced the parasite survival. That reduction in MTZ's susceptibility does not seem to be related to mutations in the genes pfor, fd, nr-1 or trxr. It points that different mechanism as alterations in other metabolic pathways can account for Giardia resistance to MTZ therapy.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Drug Resistance
/
Prodrugs
/
Giardia lamblia
/
Metronidazole
/
Antiprotozoal Agents
Тип исследования:
Risk_factors_studies
Язык:
En
Журнал:
Mem Inst Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz (Online)
/
Memórias do Instituto Oswaldo Cruz (Impresso)
/
Proceedings of the Instituto Oswaldo Cruz
Тематика журнала:
MEDICINA TROPICAL
/
PARASITOLOGIA
Год:
2020
Тип:
Article