Metástasis pancreática como debut de carcinoma papilar de tiroides: caso clínico y revisión del perfil clínico patológico y molecular / Papillary thyroid carcinoma presenting with pancreatic metastases: report of one case
Rev. méd. Chile
; 148(7): 1025-1030, jul. 2020. tab, graf
Article
в Es
| LILACS
| ID: biblio-1139405
Ответственная библиотека:
CL1.1
RESUMEN
Pancreatic metastases of papillary thyroid carcinoma (PTC) are exceptional. We report a 80-year-old man consulting for obstructive jaundice and dysphonia. Abdominal ultrasonography showed biliary dilation and abdominal magnetic resonance imaging (MRI) showed a pancreatic head mass of 36 mm. A left vocal cord paralysis was confirmed and cervical computed tomography (CT) showed multiple thyroid nodules of up to 35 mm associated with bilateral cervical lymph nodes (LN). Positron emission tomography ( 18 F-FDG PET/CT) evidenced hyper-metabolic activity in bilateral cervical LN, lungs, pancreas and left intercostal soft tissue, as well as left gluteus. Thyroid biopsy reported a tall-cell variant of PTC, and endoscopic ultrasound guided fine needle aspiration (EUS-FNA) of pancreatic mass confirmed PTC metastasis. The molecular study was positive for BRAFV600E. Pancreatic metastasis from PTC can be accurately diagnosed with 18 F-FDG PET/CT and EUS-FNA, which is consistent with a predominant expression of BRAFV600E mutation and, thus, an aggressive presentation with poor short-term survival.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Pancreatic Neoplasms
/
Thyroid Neoplasms
/
Thyroid Cancer, Papillary
Пределы темы:
Humans
Язык:
Es
Журнал:
Rev. méd. Chile
Тематика журнала:
MEDICINA
Год:
2020
Тип:
Article