Mechanism of action of glycyrrhizin against Plasmodium falciparum
Mem. Inst. Oswaldo Cruz
; 116: e210084, 2021. tab, graf
Article
в En
| LILACS
| ID: biblio-1287344
Ответственная библиотека:
BR1.1
ABSTRACT
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Triterpenes
/
Glycyrrhiza
Язык:
En
Журнал:
Mem Inst Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz (Online)
/
Memórias do Instituto Oswaldo Cruz (Impresso)
/
Proceedings of the Instituto Oswaldo Cruz
Тематика журнала:
MEDICINA TROPICAL
/
PARASITOLOGIA
Год:
2021
Тип:
Article