Pregnancy has no significant impact on the prognosis of differentiated thyroid cancer
Arch. endocrinol. metab. (Online)
; 65(6): 768-777, Nov.-Dec. 2021. tab, graf
Article
в En
| LILACS
| ID: biblio-1349988
Ответственная библиотека:
BR1.1
ABSTRACT
ABSTRACT Objective:
To evaluate the impact of pregnancy on differentiated thyroid carcinomas (DTC) behavior Subjects andmethods:
Retrospective study of patients diagnosed with DTC before or during pregnancy and treated with standard therapy. In women diagnosed with DTC before pregnancy, we evaluated the occurrence of progression according to categories of response to therapy based on imaging and non-stimulated thyroglobulin (TG) levels.Results:
Of 96 analyzed patients, 76 became pregnant after DTC treatment and 20 were diagnosed with DTC during pregnancy. Among women who became pregnant after a DTC diagnosis, no difference was observed regarding response to therapy before and after pregnancy. Disease progression after pregnancy was documented in six of these patients, while seven of them presented progression before pregnancy but were only treated after delivery. Patients with DTC diagnosed during pregnancy had a higher rate of distant metastases at diagnosis (30%) compared with the patients who became pregnant after DTC diagnosis (9.2%, p = 0.01).Conclusion:
Pregnancy had no impact on the natural course of DTC. Disease progression after pregnancy was limited and probably related to more aggressive disease and higher risk stratification at diagnosis. Still, mild disease progression may have occurred asymptomatically in some patients.Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Thyroidectomy
/
Thyroid Neoplasms
Тип исследования:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Пределы темы:
Female
/
Humans
/
Pregnancy
Язык:
En
Журнал:
Arch. endocrinol. metab. (Online)
Тематика журнала:
ENDOCRINOLOGIA
/
METABOLISMO
Год:
2021
Тип:
Article