Histological variability and the importance of clinicopathological correlation in cutaneous Rosai-Dorfman disease
An. bras. dermatol
; 91(5): 634-637, Sept.-Oct. 2016. graf
Article
в En
| LILACS
| ID: biblio-827744
Ответственная библиотека:
BR1.1
ABSTRACT
Abstract Rosai-Dorfman disease is a benign histiocytic proliferative disorder of unknown etiology. The disease mainly affects lymph node tissue, although it is rarely confined to the skin. Here, we describe a 53-year-old woman with purely cutaneous Rosai-Dorfman disease. The patient presented with a large pigmented plaque on her left leg, and sparse erythematous papules on her face and arms. A complete clinical response was achieved with thalidomide, followed by recurrence at the initial site one year later. The histological examination displayed the typical features of Rosai-Dorfman disease in the recent lesions but not in the older lesions. In the setting of no lymphadenopathy, the histopathological features of Rosai-Dorfman disease are commonly misinterpreted. Therefore, awareness of the histological aspects present at different stages, not always featuring the hallmark microscopic signs of Rosai-Dorfman disease, is particularly important for a correct diagnosis of this rare disorder.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Skin Diseases
/
Histiocytosis, Sinus
Тип исследования:
Diagnostic_studies
Пределы темы:
Adolescent
/
Female
/
Humans
Язык:
En
Журнал:
An. bras. dermatol
Тематика журнала:
DERMATOLOGIA
Год:
2016
Тип:
Article