Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China
Braz. j. infect. dis
; 21(3): 255-262, May-June 2017. tab, graf
Article
в En
| LILACS
| ID: biblio-839220
Ответственная библиотека:
BR1.1
ABSTRACT
ABSTRACT This study aimed to evaluate the protective role of statins on the development of sepsis and infection-related organ dysfunction and mortality in a hospitalized older Chinese population with bacterial infections. In this retrospective cohort study, 257 older patients with bacterial infection were divided into two groups a statin group, those who had received statin therapy for ≥1 month before admission and continued receiving statin during hospitalization; and a non-statin group, those who had never received statin or used statin for <1 month prior to admission. A multivariate logistic regression analysis was performed to identify risk and protective factors for severe sepsis. A significantly lower incidence of organ dysfunction was found in the statin group, as compared with the non-statin group (13.3% vs 31.1%, respectively; p = 0.002), corresponding to adjusted rates ratio of 0.32 (95% confidence interval [CI], 0.13-0.75; p = 0.009). No significant difference was found between statin and non-statin groups in 30-day sepsis-related mortality (4.4% vs 10.2%, respectively; p = 0.109), incidence of intensive care unit admission (13.3% vs 16.8%, respectively; p = 0.469), or length of hospital stay (20.5 vs 25.9 days, respectively; p = 0.61). Statins significantly reduced the development of sepsis and infection-related organ dysfunction in hospitalized older Chinese patients but did not reduce 30-day mortality, ICU admission incidence, or length of hospital stay.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Bacterial Infections
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Critical Illness
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Sepsis
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Multiple Organ Failure
Тип исследования:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Пределы темы:
Aged
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Aged80
/
Female
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Humans
/
Male
Страна как тема:
Asia
Язык:
En
Журнал:
Braz. j. infect. dis
Тематика журнала:
DOENCAS TRANSMISSIVEIS
Год:
2017
Тип:
Article