The percentage of resected and ischemic volume determined by a geometric model is a significant predictor of renal functional change after partial nephrectomy
Int. braz. j. urol
; 43(1): 80-86, Jan.-Feb. 2017. tab, graf
Article
в En
| LILACS
| ID: biblio-840791
Ответственная библиотека:
BR1.1
ABSTRACT
ABSTRACT Purpose The percentage of parenchyma preserved plays a predominant role in predicting renal function after partial nephrectomy (PN). Currently there is no standard method to estimate preserved renal parenchyma. In this study we propose a formula of the percentage of resected and ischemic volume (PRAIV) determined by a geometric model and evaluate the relationships between renal functional change and PRAIV as well as other clinical parameters. Materials and Methods We identified 71 patients who underwent open PN between January 2004 and April 2014. Assuming the kidney to be an ellipsoid with bilaterally equal volume and tumor to be a sphere, we calculated PRAIV by integral calculus. Nadir estimated glomerular filtration rate (eGFR) between postoperative 3 and 12 months were recorded. The correlation between percent eGFR reduction, PRAIV, and other clinical parameters were examined. Results On univariate analysis, age (p=0.03), depth of tumor invasion (p=0.004), C index (p=0.003), RAIV (p=0.04), and PRAIV (p<0.001) were correlated with percent reduction of eGFR. However, only age (p=0.007) and PRAIV (p<0.001) were significantly correlated with percent reduction of eGFR on multivariate analysis. Depicting these values along the regression line, we found R2 was 0.194 and 0.073 for PRAIV and age, respectively. Conclusions PRAIV determined by a geometric model is a significant predictor of renal functional change after PN. Using PRAIV, we can estimate percent eGFR reduction preoperatively for better patient consultation and surgical planning.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Carcinoma, Renal Cell
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Cold Ischemia
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Kidney
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Kidney Neoplasms
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Nephrectomy
Тип исследования:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Пределы темы:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Язык:
En
Журнал:
Int. braz. j. urol
Тематика журнала:
UROLOGIA
Год:
2017
Тип:
Article