Circulation levels of acute phase proteins pentraxin 3 and serum amyloid A in atherosclerosis have correlations with periodontal inflamed surface area
J. appl. oral sci
; J. appl. oral sci;26: e20170322, 2018. tab
Article
в En
| LILACS, BBO
| ID: biblio-893691
Ответственная библиотека:
BR1.1
ABSTRACT
Abstract Objectives One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included. Clinical periodontal parameters (probing depth - PD, clinical attachment loss, and bleeding on probing - BOP) were previously recorded and participants were divided into four groups after coronary angiography Group 1 CAD (+) with periodontitis (n=20); Group 2 CAD (+) without periodontitis (n=20); Group 3 CAD (-) with periodontitis (n=21); Group 4 CAD (-) without periodontitis (n = 16). Serum interleukin (IL) −1, −6, −10, tumor necrosis factor (TNF)-α, serum amyloid A (SAA), pentraxin (PTX) 3, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with ELISA. Results Groups 1 and 3 showed periodontal parameter values higher than Groups 2 and 4 (p<0.0125). None of the investigated serum parameters were statistically significantly different between the study groups (p>0.0125). In CAD (-) groups (Groups 3 and 4), PISA has shown positive correlations with PTX3 and SAA (p<0.05). Age was found to predict CAD significantly according to the results of the multivariate regression analysis (Odds Ratio 1.17; 95% Confidence Interval 1.08-1.27; p<0.001). Conclusions Although age was found to predict CAD significantly, the positive correlations between PISA and APR in CAD (-) groups deserve further attention, which might depend on the higher PISA values of periodontitis patients. In further studies conducted in a larger population, the stratification of age groups would provide us more accurate results.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Periodontitis
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Coronary Artery Disease
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Serum Amyloid A Protein
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C-Reactive Protein
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Serum Amyloid P-Component
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Atherosclerosis
Тип исследования:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Пределы темы:
Adult
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Aged
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Female
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Humans
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Male
Язык:
En
Журнал:
J. appl. oral sci
Тематика журнала:
ODONTOLOGIA
Год:
2018
Тип:
Article