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Experimental furcal perforation treated with mineral trioxide aggregate plus selenium: immune response
Espaladori, Marcela Carvalho; Maciel, Kamilla Faria; Brito, Luciana Carla Neves de; Kawai, Toshihisa; Vieira, Leda Quércia; Ribeiro Sobrinho, Antônio Paulino.
Affiliation
  • Espaladori, Marcela Carvalho; Universidade Federal de Minas Gerais. School of Dentistry. Departament of Operative Dentistry. Belo Horizonte. BR
  • Maciel, Kamilla Faria; Universidade Federal de Minas Gerais. School of Dentistry. Departament of Operative Dentistry. Belo Horizonte. BR
  • Brito, Luciana Carla Neves de; Universidade de Itaúna. School of Dentistry. Itaúna. BR
  • Kawai, Toshihisa; The Forsyth Institute. Department of Immunology. Boston. US
  • Vieira, Leda Quércia; Universidade Federal de Minas Gerais. Institute of Biological Sciences. Departament of Biochemistry and Immunology. Belo Horizonte. BR
  • Ribeiro Sobrinho, Antônio Paulino; Universidade Federal de Minas Gerais. School of Dentistry. Departament of Operative Dentistry. Belo Horizonte. BR
Braz. oral res. (Online) ; 32: e103, 2018. tab, graf
Article в En | LILACS | ID: biblio-974462
Ответственная библиотека: BR1.1
ABSTRACT
Abstract The aim of this study is to evaluate the expression of cytokines in response to mineral trioxide aggregate (MTA) plus selenium in germ-free mice with experimental furcal perforation. The first left maxillary molar was opened, and the furcal area was perforated and treated with post-MTA-Se (experimental group). The same surgical intervention was performed for the maxillary right first molar, which was treated with MTA (control group). Fifteen mice were sacrificed 7, 14, and 21 days after furcal perforation, and periapical tissue samples were collected. The mRNA expression levels of the cytokines TGF-β, TNF-α, IFN-γ, HPRT, IL-10, IL-4, RANK, RANKL, IL-1, and IL-17 were assessed by using real-time polymerase chain reaction. In the experimental group, at 21-days post-MTA-Se sealing, the mRNA levels of TNF-α and IL-10 were upregulated compared with those in the control group (p < 0.05). Futher assessment revealed basal mRNA expression levels of IL-1α, IFN-γ, RANK, RANKL, IL-17A, IL-4, and TGF-β, over long experimental times, in both the experimental and control groups (p > 0.05). In conclusion, MTA+Se sealing favoured increased expression of IL-10 and TNF-α at later time points (day 21).
Тема - темы
Key words

Полный текст: 1 База данных: LILACS Основная тема: Oxides / Root Canal Filling Materials / Selenium / Cytokines / Silicates / Furcation Defects / Calcium Compounds / Aluminum Compounds / Dental Pulp Cavity Тип исследования: Evaluation_studies / Prognostic_studies Пределы темы: Animals Язык: En Журнал: Braz. oral res. (Online) Тематика журнала: ODONTOLOGIA Год: 2018 Тип: Article

Полный текст: 1 База данных: LILACS Основная тема: Oxides / Root Canal Filling Materials / Selenium / Cytokines / Silicates / Furcation Defects / Calcium Compounds / Aluminum Compounds / Dental Pulp Cavity Тип исследования: Evaluation_studies / Prognostic_studies Пределы темы: Animals Язык: En Журнал: Braz. oral res. (Online) Тематика журнала: ODONTOLOGIA Год: 2018 Тип: Article