D-Fenfluramine selectively releases 5-HT from dorsal raphe terminals
Braz. j. med. biol. res
; 29(5): 639-42, May 1996. ilus, graf
Article
в En
| LILACS
| ID: lil-182548
Ответственная библиотека:
BR1.1
ABSTRACT
The aim of this study was to investigate whether D-fenfluramine (FEN) releases 5-hydroxytryptamine (5-HT) selectively from dorsal raphe (DR) terminais. Male Wistar rats, 180-200 g, were implanted with microdialysis probes in the amygdala (Am; N = 5) and dorsal hippocampus (DH; N = 6) and 5-HT levels were measured by electrochemical detection. Under basal conditions, 5-HT levels were approximately 50 and 230 fmol per 30 min sample, in the Am and DH, respectively. FEN (1O mg/kg, ip) produced a 3-4-fold increase in 5HT relesse in the Am, but not in the DH. Since the Am is mainly innervated by DR fibers while the DH receives 5-HT input chiefly from the median raphe (MR), the present results support the view that FEN selectively releases 5-HT from DR terminals.
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База данных:
LILACS
Основная тема:
Raphe Nuclei
/
Serotonin
/
Fenfluramine
Пределы темы:
Animals
Язык:
En
Журнал:
Braz. j. med. biol. res
Тематика журнала:
BIOLOGIA
/
MEDICINA
Год:
1996
Тип:
Article