Adhesion and co-stimulatory molecules in the pathogenesis of hepatic and intestinal schistosomiasis mansoni
Mem. Inst. Oswaldo Cruz
; 93(4): 523-9, July-Aug. 1998. ilus
Article
в En
| LILACS
| ID: lil-213334
Ответственная библиотека:
BR15.1
ABSTRACT
Infection of a susceptible host with the blood fluke Schistosoma mansoni results in the formation of periovular granulomas and subsequent fibrosis in the target organs. Granulomogenesis and fibrogenesis are mediated by immunological events which require cell-cell and cell-matrix interactions. In this review, the role of adhesion and co-stimulatory molecules in the genesis of the schistosomal pathology (granulomogenesis and fibrogenesis) is outlined. These molecules provide essential immunological interactions not only for the initiation of granuloma formation but also for the maintenance and modulation of the schistosomal granuloma during chronic infection. Furthermore, the role of secreted soluble adhesion molecules in the different clinical forms and in the modulation of the schistosomal granuloma is discussed. Recent new insights into the role of adhesion molecules for the induction of pathology by other development stages of the parasite (other than eggs) will be presented.
Полный текст:
1
База данных:
LILACS
Основная тема:
Schistosoma mansoni
/
Schistosomiasis mansoni
/
Cell Adhesion Molecules
Тип исследования:
Etiology_studies
Язык:
En
Журнал:
Mem Inst Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz (Online)
/
Memórias do Instituto Oswaldo Cruz (Impresso)
/
Proceedings of the Instituto Oswaldo Cruz
Тематика журнала:
MEDICINA TROPICAL
/
PARASITOLOGIA
Год:
1998
Тип:
Article