Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae / Serotypes and antimicrobial susceptibility of Streptococcus agalactiae
Rev. méd. Chile
; 132(5): 549-555, mayo 2004. tab
Article
в Es
| LILACS
| ID: lil-384412
Ответственная библиотека:
CL12.1
ABSTRACT
Background:
Streptococcus agalactiae or group B streptococcus, GBS, is the leading cause of neonatal and maternal infections and an opportunistic pathogen in adults with underlying disease. In the last decade, a dramatic increase in the resistance of this microorganism to erythromycin and clindamycin has been observed.Aim:
To determine the serotype distribution and antimicrobial susceptibility of isolates of S agalactiae collected from infections and colonization and to assess the genetic mechanisms of macrolide and clindamycin resistance. Material andmethods:
A total of 100 GBS isolates were collected between 1998 and 2002, in Santiago, Chile. They were isolated from the amniotic fluid from patients with premature rupture of membranes (7 isolates), blood from neonatal sepsis (10 isolates), neonate colonizations (2 strains), skin and soft tissue infections (7 isolates), urinary tract infections (5 isolates), genital infections (3 isolates), articular fluid (one isolate), and 65 strains were recovered from vaginal colonization55.Results:
Serotypes Ia, II and III were the predominant serotypes identified in our study, accounting for 90 (90 percent) of the strains. Five isolates belonged to serotypes Ib (5 percent) and two (2 percent) to serotype V respectively; no strains belonging to serotype IV were found. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four isolates (4 percent) were resistant to both erythromycin (MIC >64 µg/ml) and clindamycin (MIC >64 µg/ml). The strains had a constitutive macrolide-lincosamide-streptogramin (cMLSB) resistance phenotype and the erm(A) gene was present in the four isolates.Conclusions:
Serotypes Ia, II and III were the predominant serotypes in this study. All strains were susceptible to penicillin G, ampicillin and cefotaxime, and four (4 percent) strains were resistant to both erythromycin and clindamycin. The cMLSB resistance phenotype, and the erm(A) gene was detected in resistant strains (Rev MÚd Chile 2004; 132 549-55).
Полный текст:
1
База данных:
LILACS
Основная тема:
Streptococcus agalactiae
Язык:
Es
Журнал:
Rev. méd. Chile
Тематика журнала:
MEDICINA
Год:
2004
Тип:
Article