Relación de la genotipificación de Helicobacter pylori con la forma e intensidad de la gastritis en población adulta portadora de patología gástrica benigna / Association between helicobacter pylori genotype and the severity of gastritis in infected adults
Rev. méd. Chile
; 132(11): 1345-1354, nov. 2004. ilus, tab, graf
Article
в Es
| LILACS
| ID: lil-391838
Ответственная библиотека:
CL12.1
ABSTRACT
Background:
The damaging capacity of Helicobacter pylori is variable and depends, in part, on its genetic polymorphism.Aim:
To study H pylori genes vacA, cagA and iceA and the relationship of these genotypes with the features of acute damage in chronic gastritis. Material andmethods:
Gastric endoscopic biopsies were obtained in 75 adults for pathological study and genetic typification of H pylori by specific PCR.Results:
In only 64 cases, complete information was available. In 53 of these, there was H pylori infection demonstrated by PCR. Twenty one percent had infection by two or more H pylori strains, vacA gene had genotypes s2/m2, s1/m1 and s1/m2 in 36, 25 and 8% of cases respectively, cagA gene was present in 49% of infected patients. iceA gene had genotypes iceA 1 ad iceA 2 in 15 and 60% of patients respectively. The presence of cagA or alleles s1/m1 and s1/m2 of vacA gene was directly correlated with polymorphonuclear infiltration and the severity of epithelial damage. The genotype s2/m2 of vacA gene was significantly associated with a milder or absent mucosal damage. No association was found between iceA alleles and the pathological features of gastritis.Conclusions:
Alleles of vacA and cagA genes of H pilory are associated with the severity of gastric mucosal damage.
Полный текст:
1
База данных:
LILACS
Основная тема:
Bacterial Proteins
/
Transcription Factors
/
Helicobacter pylori
/
Helicobacter Infections
/
Gastritis
/
Genes, Bacterial
/
Antigens, Bacterial
Тип исследования:
Risk_factors_studies
Пределы темы:
Animals
/
Humans
Язык:
Es
Журнал:
Rev. méd. Chile
Тематика журнала:
MEDICINA
Год:
2004
Тип:
Article
/
Project document