Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide in patients with pulmonary tuberculosis
Braz. j. infect. dis
; Braz. j. infect. dis;13(3): 210-217, June 2009. ilus, tab, graf
Article
в En
| LILACS
| ID: lil-538522
Ответственная библиотека:
BR1.1
ABSTRACT
Intestinal barrier function and serum concentrations of rifampin, isoniazid and pyrazinamide were studied in healthy controls and patients with active pulmonary tuberculosis. A case-control study of 29 controls and 30 cases attending at the Health Center, July, 2004 to December, 2005 was conducted. The body mass index was significantly reduced in cases compared to controls (p < 0.001). The intestinal paracellular transport of lactulose was significantly (p = 0.019) reduced in cases compared to controls. The transcellular transport of mannitol and the lactulosemannitol ratio were not significantly (p = 0.0698) reduced in cases compared to controls. Low serum concentrations of rifampin, isoniazid and pyrazinamide were observed in 81 percent (48/59), 92 percent (54/59) and 28 percent (12/59), respectively, in all individuals. The results demonstrated a marked decrease on intestinal paracellular transport in patients with active pulmonary tuberculosis and reduced serum concentrations of rifampin and isoniazid in both groups.
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Tuberculosis, Pulmonary
/
Intestinal Absorption
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Antitubercular Agents
Тип исследования:
Observational_studies
Пределы темы:
Adult
/
Female
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Humans
/
Male
Язык:
En
Журнал:
Braz J Infect Dis
/
Braz. j. infect. dis
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Braz. j. infect. dis. (Online)
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Brazilian journal of infectious diseases (Impresso)
Тематика журнала:
DOENCAS TRANSMISSIVEIS
Год:
2009
Тип:
Article
/
Project document