Lard and/or canola oil-rich diets induce penile morphological alterations in a rat model
Acta cir. bras
; 29(supl.1): 39-44, 2014. tab, graf
Article
в En
| LILACS
| ID: lil-720397
Ответственная библиотека:
BR1.1
ABSTRACT
PURPOSE:
To investigate the effect of dietary lipid quantity and/or quality on penis morphology in adult rats.METHODS:
Thirty-eight male Wistar rats were divided into 4 groups normal lipid diet (NL), high-fat diet rich in saturated fatty acids (HF-S), high-fat diet rich in polyunsaturated fatty acids (HF-P), and high-fat diet rich in saturated and polyunsaturated fatty acids (HF-SP). Blood samples were collected and the penises were removed for histomorphometrical and immunohistochemical analysis.RESULTS:
All high-fat diets promoted an increase in the body mass (p<0.0001). The HF-S and HF-SP groups presented hyperglycemia (p=0.0060), hyperinsulinemia (p=0.0030), and hypercholesterolemia (p=0.0020). Concerning the penis, the high-fat diets led to an increase in the collagen fibers (p<0.0001) and smooth muscle cell density area (p=0.0027), and a decline in the sinusoidal space density area (p<0.0001) and corpus cavernosum cell proliferation (p=0.0003).CONCLUSION:
Diets rich in saturated and/or polyunsaturated fatty acids promoted overweight and induced penile changes in rodent models, which may lead to the development of erectile dysfunction. .Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Penis
/
Fatty Acids, Monounsaturated
/
Dietary Fats
/
Diet, High-Fat
/
Erectile Dysfunction
Тип исследования:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Пределы темы:
Animals
Язык:
En
Журнал:
Acta cir. bras
Тематика журнала:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Год:
2014
Тип:
Article