Clinical utility of prostate-specific antigen mass ratio for prediction of prostate cancer detection on a repeated prostate biopsy
Int. braz. j. urol
; 40(4): 484-492, Jul-Aug/2014. tab
Article
в En
| LILACS
| ID: lil-723969
Ответственная библиотека:
BR1.1
ABSTRACT
Purpose To assess the clinical utility of the prostate-specific antigen mass ratio (PSA-MR), a newly developed PSA derivative, simply defined as the (i) PSA density (PSA-D) multiplied by the plasma volume or (ii) total PSA amount in circulation per prostate volume, for predicting prostate cancer (PCa) among men undergoing repeated prostate biopsy (PBx). Materials and Methods Patients (n = 286), who underwent a repeated PBx, were analyzed. The various parameters associated with PCa detection were noted in each patient. PSA-MR was also calculated. Results PCa was detected in 63 (22.0%) of 286 patients. PSA-MR was the independent predictor in the univariate- and multivariate logistic regression analyses (OR = 3.448, p = 0.001 and OR = 13.430, p = 0.033, respectively). A nomogram that incorporated PSA-MR was considered a useful tool (predictive accuracy 79.2%, 95% CI 0.726-0.858, p < 0.001). Furthermore, a nomogram that incorporated PSA-MR would have avoided 59.6% of unnecessary repeated PBx. The predictive accuracy of PSA-MR was also superior to that of PSA or PSA-D (p = 0.013 and 0.009, respectively). Conclusions PSA-MR was an independent predictor, and its consideration would have avoided 59.6% of unnecessary repeated PBx for PCa detection. PSA-MR was also superior than PSA or PSA-D. Our results support the use of PSA-MR to facilitate counseling with patients after a negative initial PBx, and use of PSA-MR might reduce further unnecessary biopsies. .
Key words
Полный текст:
1
База данных:
LILACS
Основная тема:
Prostate
/
Prostatic Neoplasms
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Prostate-Specific Antigen
Тип исследования:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Пределы темы:
Aged
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Humans
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Male
Язык:
En
Журнал:
Int. braz. j. urol
Тематика журнала:
UROLOGIA
Год:
2014
Тип:
Article