An updated meta-analysis of the relationship between glutathione S-transferase T1 null/presence gene polymorphism and the risk of lung cancer
J Cancer Res Ther
; 2020 Sep; 16(4): 718-725
Article
| IMSEAR
| ID: sea-213692
ABSTRACT
Aim of Study There were many reports published on the relationship between glutathione S-transferase T1 (GSTT1) null/presence gene polymorphism and the risk of lung cancer in these years. In previous, we conducted a meta-analysis to evaluate the relationship between GSTT1 null/presence gene polymorphism and the risk of lung cancer. This study was conducted to update it. Materials and Methods:
The association studies were identified from PubMed and Cochrane Library on March 1, 2016.Results:
Sixty-three reports were recruited into this meta-analysis for the association of null genotype of GSTT1 with lung cancer susceptibility, consisting of 21,220 patients with lung cancer and 21,496 controls. There was a marked association between GSTT1 null genotype and lung cancer risk in overall populations and in Asians (overall populations Odds ratio [OR] = 1.17, 95% confidence interval [95% CI] 1.07–1.28, P = 0.006; Asians OR = 1.41, 95% CI 1.23–1.62, P < 0.00001). However, GSTT1 null genotype was not associated with the risk of lung cancer in Caucasians, Brazilian population, and Africans.Conclusion:
GSTT1 null genotype is associated with the lung cancer risk in overall populations and in Asians
Полный текст:
1
База данных:
IMSEAR
Тип исследования:
Etiology_studies
/
Systematic_reviews
Журнал:
J Cancer Res Ther
Тематика журнала:
Neoplasms
/
Therapeutics
Год:
2020
Тип:
Article