Circulating tumour necrosis factor alpha & soluble TNF receptors in patients with Guillain-Barre syndrome.
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| IMSEAR
| ID: sea-23886
ABSTRACT
BACKGROUND & OBJECTIVES:
Tumour necrosis factor-alpha (TNF-alpha) is regarded as one of the immune factors that can induce demyelination of peripheral nerves in patients with Guillian-Barre syndrome (GBS). This present study was undertaken to find out the role of TNF-alpha and soluble TNF receptors in the pathogenesis of GBS; and to study the effect of intravenous immunoglobulin (ivIg) therapy on the serum TNF-alpha and soluble TNF receptors in patients with GBS.METHODS:
Thirty six patients with GBS in progressive stages of motor weakness were included in this study. The serum TNF-alpha and soluble TNF receptors (TNF-RI, TNF-RII) were measured in the serum samples of these patients before and after ivIg therapy by a sandwich ELISA.RESULTS:
Of the 36 patients with GBS, 26 (72.2%) showed elevated serum TNF-alpha levels prior to ivIg therapy. Following a complete course of ivIg therapy there was a progressive decrease in the serum TNF-alpha concentrations in these 26 patients. On the other hand, the soluble TNF receptors, particularly TNF-RII showed an increase in the serum of GBS patients following ivIg therapy. INTERPRETATION &CONCLUSION:
The results indicate that ivIg reduces the serum TNF-alpha concentrations in the GBS patients having elevated levels prior to ivIg therapy. Elevated serum levels of soluble TNF receptors following ivIg therapy may play a protective role by inhibiting the demyelinating effect of TNF-alpha in the peripheral nerves of patients with GBS.
Полный текст:
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База данных:
IMSEAR
Основная тема:
Female
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Humans
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Male
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Child
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Adolescent
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Tumor Necrosis Factor-alpha
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Immunoglobulins, Intravenous
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Receptors, Tumor Necrosis Factor
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Adult
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Guillain-Barre Syndrome
Язык:
En
Год:
2003
Тип:
Article