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Research progress of nitrobenzoyl sesquiterpenoids as marine characteristic natural products / 药学学报
Acta Pharmaceutica Sinica ; (12): 35-42, 2024.
Article в Zh | WPRIM | ID: wpr-1005437
Ответственная библиотека: WPRO
ABSTRACT
Sesquiterpenoids are widely found in nature, while nitrobenzoyl sesquiterpenoids are relatively rare. Twelve natural nitrobenzoyl sesquiterpenoids were all derived from marine Aspergillus fungi, which are typical natural products with marine characteristics. These natural products exhibit good antitumor, antiviral, and inhibition of osteoclast differentiation activity, especially in the treatment of osteoclast-related diseases, showing good medicinal development value. This article reviews the natural product sources, chemical structure, chemical synthesis, biosynthesis, bioactivity, and pharmacological mechanisms of nitrobenzoyl sesquiterpenoids and predicts and discusses their absorption, distribution, metabolism, excretion, toxicity (ADME/T), and drug-likeness, providing a comprehensive understanding of the natural products of nitrobenzoyl sesquiterpenoids from marine sources and their potential for pharmaceutical development.
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Полный текст: 1 База данных: WPRIM Язык: Zh Журнал: Acta Pharmaceutica Sinica Год: 2024 Тип: Article
Полный текст: 1 База данных: WPRIM Язык: Zh Журнал: Acta Pharmaceutica Sinica Год: 2024 Тип: Article