Research progress in epigenetic pharmacological effects of rhein / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 6545-6550, 2023.
Article
в Zh
| WPRIM
| ID: wpr-1008854
Ответственная библиотека:
WPRO
ABSTRACT
Rhein, which is one of the main active components of Rheum palmatum, has a range of pharmacological activities such as the regulation of the metabolism of glucose and lipids, anti-inflammatory, anti-tumor, anti-fibrosis, etc. Epigenetics refers to the heritable variation of gene expression without altering the DNA sequence. It is involved in the emergence and development of inflammation, renal fibrosis, diabetes, cancer, atherosclerosis, and other diseases, thus becoming a new strategy for the treatment of many di-seases. A series of studies have shown that epigenetic modification may be a common molecular mechanism of various pharmacological effects of rhein. This paper summarized the effects of rhein on the regulation of epigenetic modification and its underlying mechanisms, which involve the regulation of DNA methylation, protein acetylation, and RNA methylation, so as to provide a basis for the development and application of rhein.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Fibrosis
/
Anthraquinones
/
DNA Methylation
/
Epigenesis, Genetic
/
Neoplasms
Пределы темы:
Humans
Язык:
Zh
Журнал:
China Journal of Chinese Materia Medica
Год:
2023
Тип:
Article