Research Progress of Iron Metabolism in Disease Progression and Drug Resistance of Multiple Myeloma--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1916-1920, 2023.
Article
в Zh
| WPRIM
| ID: wpr-1010060
Ответственная библиотека:
WPRO
ABSTRACT
Iron metabolism is involved in the development and drug resistance of many malignancies, including multiple myeloma (MM). Based on recent studies on iron metabolism and MM, this paper reviews the relationship between iron metabolism and disease process of MM in terms of iron overload leading to ferroptosis in MM cells, the role of iron deficiency in oxidative respiration and proliferation of MM cells, and the interaction between ferroptosis and autophagy in the disease process. The mechanisms by which iron metabolism-related substances lead to MM cells' resistance to proteasome inhibitors (PI) through inducing redox imbalance and M2 macrophage polarization are also briefly described, aiming to provide a theoretical basis for the application of iron metabolism-related drugs to the clinical treatment of MM patients.
Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Autophagy
/
Disease Progression
/
Drug Resistance, Neoplasm
/
Iron
/
Multiple Myeloma
Пределы темы:
Humans
Язык:
Zh
Журнал:
Journal of Experimental Hematology
Год:
2023
Тип:
Article