Hypothesis of Genetic Diversity Selection in the Occurrence and Development of
Lung Cancer: Molecular Evolution and Clinical Significance / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 943-949, 2024.
Article
в Zh
| WPRIM
| ID: wpr-1010102
Ответственная библиотека:
WPRO
ABSTRACT
So far, the monoclonal hypothesis of tumor occurrence and development cannot be justified. The genetic diversity selection hypothesis for the occurrence and development of lung cancer links Mendelian genetics with Darwin's theory of evolution, suggesting that the genetic diversity of tumor cell populations with polyclonal origins-monoclonal selection-subclonal expansion is the result of selection pressure. Normal cells acquire mutations in oncogenic driver genes and have a selective advantage over other cells, becoming tumor initiating cells; In the interaction with the tumor microenvironment (TME), the vast majority of initiating cells are recognized and killed by the human immune system. If immune escape occurs, the incidence of malignant tumors will greatly increase, and subclonal expansion, intratumour heterogeneity, etc. will occur. This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance.
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Key words
Полный текст:
1
База данных:
WPRIM
Основная тема:
Evolution, Molecular
/
Tumor Microenvironment
/
Clinical Relevance
/
Lung Neoplasms
/
Mutation
Пределы темы:
Humans
Язык:
Zh
Журнал:
Chinese Journal of Lung Cancer
Год:
2024
Тип:
Article