Effects of SIRT1 on morphine-induced conditioned place preference in rats through CREB/BDNF pathway / 中国药理学通报
Chinese Pharmacological Bulletin
; (12): 1263-1270, 2023.
Article
в Zh
| WPRIM
| ID: wpr-1013924
Ответственная библиотека:
WPRO
ABSTRACT
Aim To investigate the effect of microinjection of EX527, a selective SIRT1 antagonist, into the ventrolateral orbital cortex (VLO) on morphine-induced conditioned place preference (CPP), and to explore the role of CREB/BDNF in it. Methods The cannulas were implanted bilaterally in the VLO of rats by brain stereotaxis surgery, and the model of morphine-induced CPP was established. The behavioral experiment consisted of four stages:habituation (d 1), pre-test (d 2-4), conditioning training (d 5-14) and test (d 15). At the stage of conditioning training, EX527 (1 μL, 5 g·L
Полный текст:
1
База данных:
WPRIM
Язык:
Zh
Журнал:
Chinese Pharmacological Bulletin
Год:
2023
Тип:
Article