Research progress on the mechanism of autophagy's role in perioperative neurocognitive disorders / 临床麻醉学杂志

ABSTRACT

Perioperative neurocognitive disorders commonly manifest as impaired memory and con-fusion in patients,prolonged hospitalisation,poor prognosis,and increased mortality.Autophagy is closely related to the onset of perioperative neurocognitive disorder.Drugs,aging and inflammation affect autophagy levels by regulating signaling pathways such as mTOR and FOXO1,which are involved in the pathogenesis of perioperative neurocognitive disorder.Autophagy plays an important role in improving postoperative cogni-tive dysfunction and learning memory by modulating neuroinflammation,α-synuclein,and τ protein metabo-lism.This article reviews the main pathways regulating autophagy and the role of autophagy in the occurrence and development of perioperative neurocognitive disorders,in order to seek new targets and ideas for the pathogenesis of perioperative neurocognitive disorders.