Recognition of intestinal mucosal immunopathogenesis of IgA nephropathy: gut-derived IgA + plasma cells / 中华实用儿科临床杂志

ABSTRACT

Gut-derived IgA + plasma cells are the key to intestinal mucosal immunity.The intestinal flora and diet regulate the production of gut-derived IgA + plasma cells, which not only play an immune role in the intestinal mucosa, but also migrate to tissues or organs outside the intestine to regulate immune and inflammatory reactions by relying on the production of IgA antibodies or the secretion of cytokines and other non-antibody effects, and act as a protective or pathogenic factor in various diseases.The pathogenic effect of intestinal mucosal immune imbalance in IgA nephropathy (IgAN) has been a concern.IgA + plasma cells increase in intestinal lamina propria of high serum IgA mice with the increase of abnormally glycosylated IgA1.The long-lived plasma cells increase, and interleukin-6 is inhibited in IgAN patients.However, it remains unclear whether gut-derived IgA + plasma cells migrate to kidneys to promote disease progression.This article reviews the relevant research progress on the immunopathologic effects and mechanisms of gut-derived IgA + plasma cells in the intestinal mucosa of IgAN.