Efficacy Observation and Tolerance Analysis of Pulsed Low-dose Rate Radiotherapy in Secondary Radiotherapy for Recurrent Esophageal Cancer / 医学研究杂志

ABSTRACT

Objective To investigate the efficacy and tolerance of pulsed low-dose rate radiotherapy in secondary radiotherapy for recurrent esophageal cancer.Methods A total of 80 patients with esophageal cancer admitted to Department of Oncology,Affiliated Hos-pital of Yangzhou University from January 2018 to December 2019,all of whom had previously received chest radiation therapy and had re-currence in the radiation field,they were divided into two groups by simple random sampling method:experimental group and control group,with 40 cases in each group.The patients of experimental group received pulsed low-dose rate radiotherapy,and the patients of control group received conventional intensity modulated radiotherapy,respectively.The efficacy and tolerance of the two groups were ob-served.Results The patients of experimental group had a higher objective response rate(80%vs 40%,P =0.010),and a lower inci-dence of common adverse effects(5%vs 30%,P = 0.037).The incidence of late moderate and severe radiation damage was lower(30%vs 75%,P =0.004),the incidence of acute radiation damage was lower(25%vs 65%,P =0.011),and the 1-year survival rate was higher(85%vs 45%,P = 0.008).Although there was no significant difference in 2-year survival(25%vs 5%,P = 0.077),the experimental group was still higher than the control group.Conclusion Pulsed low-dose rate radiotherapy has significant clinical efficacy,and has a good protective effect on adjacent organs,and brings less adverse reactions,so it is a better choice of seconda-ry radiotherapy for patients with recurrent esophageal cancer.