Influences of preoperative 3DCRT on the curative effect and platelet parameters of colon cancer / 中国医学装备

ABSTRACT

Objective:To analyze the influences of preoperative three-dimensional conformal radiation therapy(3DCRT)on the curative effect and platelet parameters of colon cancer.Methods:A total of 110 patients with colon cancer admitted to hospital were selected and they were divided into a control group(62 cases)and an observation group(58 cases)according to different treatment methods.The control group was given conventional radiotherapy,and the observation group was given preoperative 3DCRT.The platelet parameters before and after radiotherapy were compared between the two groups.And then,the follow-up was conducted for the local control rate,survival rate and the incidence rate of complication during 1-3 years treatment after radiotherapy,and the results were counted as statistic methods.Results:Platelet(PLT)and mean platelet volume(MPV)of two groups after treatment were significantly lower than those before treatment(tobservation group=7.407,t=5.733,tcontrol group=4.977,t=2.589,P<0.05),respectively.After radiotherapy,the PLT,MPV and procalcitonin(PCT)levels of observation group were significantly lower than those of control group(t=2.256,t=4.165,t=2.737,P<0.05),respectively.The local control rate and survival rate at 1,2 and 3 years of follow-up of the observation group were significantly higher than those of the control group,and the differences were statistically significant(x2local control rate=4.359,x2=3.944,x2=3.910,x2survival rate=3.986,x2=4.270,x2=0.011,P<0.05),respectively.There were no significant differences in the reduction rate of white blood cell,the incidence of advanced complications and the incidence of systemic reactions during treatment between two groups(x2=0.187,x2=0.006,x2=0.011,P>0.05).Conclusion:Preoperative 3DCRT can achieve higher resection rate of tumor in treating colon cancer,which can effectively regulate platelet parameters,and significantly improve local control rate and survival rate in the treatment of colon cancer.The incidence of the relative adverse reactions of radiotherapy is low,and patients can tolerate it.