Application of high perfusion therapy combined with fasudil and prostaglanddin E1 in patents with cerebral infarction after receiving surgery for severe traumatic brain injury / 中华神经医学杂志

ABSTRACT

Objective To investigate the traumatic cerebral infarction treatment in patients with severe craniocerebral trauma combined with cerebral hernia after performing large decompressive craniectomy.Methods Thirty-two patients with cerebral infarction after receiving decompressive craniectomy for severe traumatic brain injury combined with brain hernia,admitted to our hospital from January 2009 to April 2012,were chosen in our study; these patients were given saline (35 mL) +dopamine (100 mg)+Aramine (50 mg) micro-pump infusion for 2-3 mL/h,24 hours of high perfusion combined with fasudil and prostaglanddin E1 for antispasmodic therapy.The clinical data and treatment efficacy of these patients were retrospectively analyzed.Results Postoperative head CT confirmed the disappearance of infarction focuses and good recovery of brain tissues,including cure in 17 patients,good recovery in 12,mild disability and severe disability in 1; no persistent vegetative state or death were noted.Conclusion Under the premise of full blood volume,high perfusion combined with fasudil and prostaglanddin E1 for antispasmodic treatment enjoys good effect in patients with severe craniocerebral trauma combined with cerebral hernia after performing large decompressive craniectomy,which is economical,practical,and worthy to be popularized.