Cannabidiol improves cognitive impairment in dementia model rats by regulating the expression of AMPA receptor in the brain / 中风与神经疾病杂志
Journal of Apoplexy and Nervous Diseases
; (12): 596-600, 2022.
Article
в Zh
| WPRIM
| ID: wpr-1038907
Ответственная библиотека:
WPRO
ABSTRACT
@#To observe the effects of cannabidiol(CBD)on cognitive function and AMPA receptor expression in sporadic Alzheimer’s disease(sAD)rats induced by bilateral intraventricular injection of streptozotocin(STZ). MethodsForty adult male Sprague-Dawley(SD)rats were randomly divided into four groups:sham operation group(S),cannabidiol(CBD)+ sham operation group(CBD+S),model group(STZ),CBD+model group(CBD+STZ). The cognitive function of rats was tested by Morris water maze(MWM)and step-down test. Western blot was used to detecte the expression of GluR1 and GluR2 in the cerebral cortex and hippocampus. ResultsIn the Morris water maze test,compared with the S group,the escape latency in the STZ group was significantly prolonged(P<0.01),and the escape latency in the CBD+STZ group was significantly shortened(P<0.01). In the step-down test,compared with the latency and the number of errors in the S group,the latency in the STZ group was significantly shortened(P<0.01),and the number of errors was significantly increased(P<0.01). Compared with the STZ group,the latency of CBD+STZ group was significantly prolonged(P<0.05),and the number of errors of CBD+STZ group was significantly reduced(P<0.05). Compared with the STZ group,the contents of GluR1 in cortex and hippocampus of the CBD+STZ group were significantly(P<0.01)(P<0.05)decreased. Compared with STZ group,the contents of GluR2 in cortex and hippocampus of the CBD+STZ group were significantly(P<0.01)(P<0.01)decreased. ConclusionCannabidiol improves STZ-induced cognitive impairment in rats by regulating AMPA receptor expression in the brain.
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База данных:
WPRIM
Язык:
Zh
Журнал:
Journal of Apoplexy and Nervous Diseases
Год:
2022
Тип:
Article