Cannabidiol improves cognitive impairment in dementia model rats by regulating the expression of AMPA receptor in the brain / 中风与神经疾病杂志

ABSTRACT

@#To observe the effects of cannabidiol（CBD）on cognitive function and AMPA receptor expression in sporadic Alzheimer’s disease（sAD）rats induced by bilateral intraventricular injection of streptozotocin（STZ）. MethodsForty adult male Sprague-Dawley（SD）rats were randomly divided into four groups：sham operation group（S），cannabidiol（CBD）+ sham operation group（CBD+S），model group（STZ），CBD+model group（CBD+STZ）. The cognitive function of rats was tested by Morris water maze（MWM）and step-down test. Western blot was used to detecte the expression of GluR1 and GluR2 in the cerebral cortex and hippocampus. ResultsIn the Morris water maze test，compared with the S group，the escape latency in the STZ group was significantly prolonged（P<0.01），and the escape latency in the CBD+STZ group was significantly shortened（P<0.01）. In the step-down test，compared with the latency and the number of errors in the S group，the latency in the STZ group was significantly shortened（P<0.01），and the number of errors was significantly increased（P<0.01）. Compared with the STZ group，the latency of CBD+STZ group was significantly prolonged（P<0.05），and the number of errors of CBD+STZ group was significantly reduced（P<0.05）. Compared with the STZ group，the contents of GluR1 in cortex and hippocampus of the CBD+STZ group were significantly（P<0.01）（P<0.05）decreased. Compared with STZ group，the contents of GluR2 in cortex and hippocampus of the CBD+STZ group were significantly（P<0.01）（P<0.01）decreased. ConclusionCannabidiol improves STZ-induced cognitive impairment in rats by regulating AMPA receptor expression in the brain.